Consultant for Etomidate Freebase Synthesis

We are seeking an experienced organic chemist, medicinal chemist, pharmaceutical process-development chemist, or pharmaceutical research consultant with relevant experience in API/process chemistry and preferably familiarity with Etomidate Freebase (CAS 33125-97-2) or closely related pharmaceutical synthesis and process-development work.

Project Objective

Our team will perform the laboratory work locally in the Philippines. We are looking for an external technical consultant who can recommend the most practical process approach and guide our team through route selection, process development, analytical considerations, troubleshooting, optimisation, and technical documentation.

The intended application is R&D, technical training, process development, and knowledge transfer.

The target is approximately 200 g of isolated R-(+)-Etomidate freebase, subject to final technical review, laboratory capability, regulatory requirements, and agreed specifications.

Scope of Technical Support

The selected consultant should be able to support:

KSM / starting-material and route selection

Evaluation and comparison of practical synthetic routes

Process-development and optimisation recommendations

Raw-material, reagent, solvent, and consumables planning

Laboratory-equipment requirements

Analytical strategy and purity / impurity considerations

Process monitoring and interpretation of laboratory results

Troubleshooting during execution

Scale-up considerations relevant to the proposed laboratory scale

Laboratory handling and storage considerations

Knowledge transfer and technical training

Final technical / process documentation

Our team will conduct the laboratory execution. The consultant's role is to provide technical direction, documentation, review, troubleshooting, and process-development guidance throughout the agreed scope.

Current Laboratory Equipment

We currently have access to:

Fume hood

Standard borosilicate glassware and round-bottom flasks

Magnetic stirrer / hot plate and heating mantle

Thermometer / temperature probe

Ice bath / basic cooling setup

Reflux condenser

Separatory funnel

Vacuum filtration / Büchner setup

Analytical balance

pH paper

Drying oven

If additional standard and readily available laboratory equipment is required, please identify it in your proposal. We may be able to procure additional equipment quickly if it is reasonably priced and readily available locally.

Preference will be given to process approaches that can be executed mainly with standard organic-chemistry laboratory equipment and that minimize the need for highly specialized or difficult-to-source equipment.

What We Want to See in Your Proposal

Please provide sufficient technical detail for us to properly evaluate and compare your proposed approach before selecting a consultant.

The complete proposed SOP / process procedure must be included as part of your proposal so that our team can review the route, required materials, equipment, process practicality, and overall feasibility before selecting a consultant.

Your proposal should include:

Your recommended KSM / starting-material strategy

The route or route options you consider most practical

Approximate number of process stages

Comparison of the proposed route with alternative routes you would consider

Why your preferred approach is suitable for approximately 200 g scale

Complete list of required raw materials, KSMs, reagents, solvents, consumables, and critical materials

Equipment required beyond what we already have

Analytical/testing requirements

Expected major technical challenges or risk points

Your proposed process-development and optimisation strategy

The complete proposed SOP / process procedure for your recommended route

Process controls, monitoring requirements, and important decision points that our team should follow

How you would guide our team during laboratory execution

How troubleshooting and process adjustments would be handled

What support you would provide if the initial execution requires optimisation or adjustment

Proposed milestones, timeline, and commercial terms

The complete SOP is an important part of our proposal evaluation. We want to review the proposed process before choosing a consultant so that we can compare the practicality, complexity, equipment requirements, material availability, development risk, and overall suitability of each candidate's approach.

Applicants who provide only a general description of the route without sufficient process documentation may not provide enough information for us to properly evaluate the proposal.

We would also like to understand what additional documentation you can provide as part of the engagement, including the final process/SOP package, analytical information, observations, troubleshooting guidance, optimisation recommendations, and technical-transfer documentation.

After reviewing the proposals and confirming the preferred route and procedure, we will select the consultant and proceed with the agreed project scope and technical guidance.

Preferred Route Characteristics

Our priorities are:

Simple and practical execution

Minimum number of difficult process steps

Readily available KSMs and raw materials

Reasonable development and manufacturing cost

Low practical risk of batch failure

Minimal reliance on specialized equipment

Suitable for technical training and future process transfer

Reproducible and well documented

Candidate Background

Preference will be given to candidates with demonstrated experience in:

Organic synthesis

Pharmaceutical process chemistry

Medicinal chemistry

API process development

CMC / pharmaceutical development

Analytical characterization

Impurity and purity assessment

Process scale-up

Technology transfer

CRO/CDMO or pharmaceutical manufacturing environments

Please briefly describe relevant projects you have completed and the level of hands-on involvement you had in route development, optimisation, scale-up, troubleshooting, and technology transfer.

Please submit your complete proposed technical approach, recommended route, complete SOP/process procedure, required materials and equipment, scope of support, deliverables, timeline, and quotation as part of your proposal.